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Abstract The evolutionary path of massive stars begins at helium burning. Energy production for this phase of stellar evolution is dominated by the reaction path 3$$\alpha \rightarrow ^{12}$$ $\alpha {\to }^{12}$C$$(\alpha ,\gamma )^{16}$$ ${(\alpha ,\gamma )}^{16}$O and also determines the ratio of$$^{12}$$ $_{}^{12}$C/$$^{16}$$ $_{}^{16}$O in the stellar core. This ratio then sets the evolutionary trajectory as the star evolves towards a white dwarf, neutron star or black hole. Although the reaction rate of the 3$$\alpha $$ $\alpha$process is relatively well known, since it proceeds mainly through a single narrow resonance in$$^{12}$$ $_{}^{12}$C, that of the$$^{12}$$ $_{}^{12}$C$$(\alpha ,\gamma )^{16}$$ ${(\alpha ,\gamma )}^{16}$O reaction remains uncertain since it is the result of a more difficult to pin down, slowly-varying, portion of the cross section over a strong interference region between the high-energy tails of subthreshold resonances, the low-energy tails of higher-energy broad resonances and direct capture. Experimental measurements of this cross section require herculean efforts, since even at higher energies the cross section remains small and large background sources are often present that require the use of very sensitive experimental methods. Since the$$^{12}$$ $_{}^{12}$C$$(\alpha ,\gamma )^{16}$$ ${(\alpha ,\gamma )}^{16}$O reaction has such a strong influence on many different stellar objects, it is also interesting to try to back calculate the required rate needed to match astrophysical observations. This has become increasingly tempting, as the accuracy and precision of observational data has been steadily improving. Yet, the pitfall to this approach lies in the intermediary steps of modeling, where other uncertainties needed to model a star’s internal behavior remain highly uncertain. 

Abstract We review recent progress and motivate the need for further developments in nuclear optical potentials that are widely used in the theoretical analysis of nucleon elastic scattering and reaction cross sections. In regions of the nuclear chart away from stability, which represent a frontier in nuclear science over the coming decade and which will be probed at new rare-isotope beam facilities worldwide, there is a targeted need to quantify and reduce theoretical reaction model uncertainties, especially with respect to nuclear optical potentials. We first describe the primary physics motivations for an improved description of nuclear reactions involving short-lived isotopes, focusing on its benefits for fundamental science discoveries and applications to medicine, energy, and security. We then outline the various methods in use today to build optical potentials starting from phenomenological, microscopic, andab initiomethods, highlighting in particular, the strengths and weaknesses of each approach. We then discuss publicly-available tools and resources facilitating the propagation of recent progresses in the field to practitioners. Finally, we provide a set of open challenges and recommendations for the field to advance the fundamental science goals of nuclear reaction studies in the rare-isotope beam era. This paper is the outcome of the Facility for Rare Isotope Beams Theory Alliance (FRIB-TA) topical program ‘Optical Potentials in Nuclear Physics’ held in March 2022 at FRIB. Its content is non-exhaustive, was chosen by the participants and reflects their efforts related to optical potentials.